Rare Autoimmune Diseases 

The autoimmune diseases known to exist, it could be said that the majority of them are considered uncommon, which unfortunately also means there's relatively small information out there reporting exactly how rare. Other immune system infections, such as Sjogren’s syndrome, systemic vasculitis, vasculitis limited to the skin, systemic sclerosis, polymyositis/dermatomyositis, and other systemic inclusion of connective tissue, are generally uncommon in ladies of childbearing age. Connective tissue diseases are disorders featuring abnormalities including the collagen and elastin. Connective tissue infections are frequently characterized by a variety of immune abnormalities that are common for each particular sort of illness.
Mixed connective tissue disease (MTCD) is a rare inflammatory rheumatic disease. MCTD may be a particular subset of the broader category “overlap syndromes”, a term utilized to portray when a patient has features of more than one classic inflammatory rheumatic infection. Mixed connective tissue disease is considered a "cover" of three connective tissue infections, systemic lupus erythematosus, scleroderma, and polymyositis. Diagnosis of MTCD is supported by identifying irregular antibodies within the blood. The side effects of MCTD usually appear up in sequence over a number of years, not all at once. About 90 % of individuals with MCTD have Raynaud’s phenomenon. This is often a condition characterized by extreme assaults of cold, numb fingers that become blue, white, or purple. It some of the time happens months or a long time before other indications. 
The treatment of MCTD is based upon the specific side effects that show in each case. In spite of the fact that, no controlled studies have been performed in MCTD, a few patients with MCTD have been included in past trials of lupus, scleroderma, myositis, and rheumatoid joint pain patients. Corticosteroids are ordinarily successful, particularly when the disease is analyzed early. Mild cases can be treated with nonsteroidal anti-inflammatory drugs, hydroxychloroquine or comparable drugs, or exceptionally low doses of corticosteroids. The more extreme the disease, the higher the dose of corticosteroid required. In serious cases, immunosuppressive drugs (such as azathioprine, methotrexate, or cyclophosphamide) may too be needed.
Medications used to treat MCTD include:
·        Nonsteroidal anti-inflammatory drugs (NSAIDs)
·        Corticosteroids
·        Calcium channel blockers
·        Immunosuppressants
·        Pulmonary hypertension drugs
·        Antimalarial drugs 

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